Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

摘要

Heat-map representation of DEGs in ToF compared to ASD atrium tissues. Data shown are relative to gene expression of atrium tissues from 10 ToF and 10 ASD patients undergoing cardiac surgery profiled by microarray. The heat-map shows the expression levels of genes differentially expressed in ToF vs ASD samples. Expression levels were z-scored and log2 transformed and are indicated by a 2-color scale ranging from blue (lowest values) to red (highest values). The 2-color scale is reported in the horizontal bar at the top of the figure. Each column represents a patient and each row represents a gene. The gene symbols are listed on the right side of the heatmap, whereas the disease type is indicated on the top side