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Efficacy and Safety of MMFS-01 a Synapse Density Enhancer for Treating Cognitive Impairment in Older Adults: A Randomized Double-Blind Placebo-Controlled Trial

机译：MMFS-01（一种突触密度增强剂）用于治疗老年人的认知障碍的功效和安全性：一项随机双盲安慰剂对照的试验

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摘要

Background:Cognitive impairment is a major problem in elderly, affecting quality of life. Pre-clinical studies show that MMFS-01, a synapse density enhancer, is effective at reversing cognitive decline in aging rodents.

机译：背景：认知障碍是老年人的主要问题，影响生活质量。临床前研究表明，MMFS-01是一种突触密度增强剂，可有效逆转衰老啮齿动物的认知能力下降。

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期刊名称 IOS Press Open Library
作者
Guosong Liu; Jason G. Weinger; Zhong-Lin Lu; Feng Xue; Safa Sadeghpour;
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作者单位

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年(卷),期 -1(49),4
年度 -1
页码 971–990
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
Alzheimer’s disease cognitive impairment cognition composite score L-threonate magnesium mild cognitive impairment randomized clinical trial sleep disorder synaptic density;

机译：阿尔茨海默氏病;认知障碍;认知;综合评分;L-苏氨酸;镁;轻度认知障碍;随机临床试验;睡眠障碍;突触密度;

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专利

1. Efficacy and Safety of MMFS-01, a Synapse Density Enhancer, for Treating Cognitive Impairment in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial [J] . Guosong Liu, Jason G. Weinger, Zhong-Lin Lu, Journal of Alzheimer's disease: JAD . 2016,第4期

机译：MMFS-01（一种突触密度增强剂）用于治疗老年人的认知障碍的功效和安全性：一项随机，双盲，安慰剂对照的试验
2. Efficacy of Cognition Support Formula? on cognitive function in older adults with subjective cognitive impairment: a protocol for a 26-week, randomised, double-blind, placebo-controlled trial [J] . Adele E. Cave, Dennis H. Chang, Gerald W. Münch, Trials . 2019,第1期

机译：认知支持公式的疗效？关于具有主观认知障碍的老年人认知功能：一个26周，随机，双盲，安慰剂对照试验的议定书
3. Evaluation of the Efficacy, Safety, and Tolerability of BI 409306, a Novel Phosphodiesterase 9 Inhibitor, in Cognitive Impairment in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled, Phase II Trial [J] . Brown David, Nakagome Kazuyuki, Cordes Joachim, Schizophrenia bulletin . 2019,第2期

机译：评估BI 409306，一种新型磷酸二酯酶9抑制剂的疗效，安全性和可耐药性，在精神分裂症中的认知障碍：随机，双盲，安慰剂控制，II期试验
4. A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL TRIAL TO INVESTIGATE THE EFFICACY OF TIAMULIN IN THE CONTROL OF PORCINE PROLIFERATIVE ENTEROPATHY (PPE) AND PORCINE COLONIC SPIROCHAETOSIS (PCS) UNDER FIELD CONDITIONS [C] . J. Haugegaard, K. Moller, T.K. Jensen, Congress of the International Pig Veterinary Society . 2000

机译：一种双盲随机安慰剂对照临床试验，探讨硫霉素在野生植物中猪增殖肠病（PPE）和猪结肠螺旋肌肤症（PCS）的疗效
5. A Randomized, Double-blind, Placebo-controlled Clinical Trial Evaluating the Effect of Infliximab on General Cognition in a Population of Depressed Individuals with Bipolar Disorder Type I/II [D] . Pan, Zihang. 2018

机译：一项随机，双盲，安慰剂对照的临床试验，评估英夫利昔单抗对I / II型双相情感障碍抑郁症患者总体认知的影响
6. Evaluation of the Efficacy Safety and Tolerability of BI 409306 a Novel Phosphodiesterase 9 Inhibitor in Cognitive Impairment in Schizophrenia: A Randomized Double-Blind Placebo-Controlled Phase II Trial [O] . David Brown, Kazuyuki Nakagome, Joachim Cordes, 2019

机译：精神分裂症认知障碍中新型磷酸二酯酶9抑制剂BI 409306的功效安全性和耐受性评估：一项随机双盲安慰剂对照的II期试验
7. Rationale and design of a double-blind, placebo-controlled, randomized trial to evaluate the safety and efficacy of nimodipine in preventing cognitive impairment in ischemic cerebrovascular events (NICE) [O] . Penglian Wang, Yongjun Wang, Tao Feng, 2012

机译：一项双盲，安慰剂对照，随机试验的原理和设计，用于评估尼莫地平预防缺血性脑血管事件（NICE）的认知障碍的安全性和有效性

Efficacy and Safety of MMFS-01 a Synapse Density Enhancer for Treating Cognitive Impairment in Older Adults: A Randomized Double-Blind Placebo-Controlled Trial

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