UNDERSTANDING NIH CLINICAL CASE DEFINITIONS FOR PEDIATRIC INTRATHORACIC TB BY APPLYING THEM TO A CLINICAL TRIAL

摘要

Setting and ObjectiveCurrently, standardized clinical case definitions represent the best option for pediatric tuberculosis (TB) disease diagnosis and classification. We applied clinical case definitions for intrathoracic TB classification, developed by an expert panel for use in reporting diagnostic studies with passive case finding, to TB suspects from IMPAACT P1041, a trial of INH prophylaxis in healthy HIV-exposed, BCG vaccinated infants which employed active surveillance, to assess novel application of these guidelines in this setting.