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Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

机译：Perilipin 5通过激活INS-1胰腺β细胞中PI3K / ERK介导的Nrf2-ARE信号通路减少与脂质毒性相关的氧化损伤。

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期刊名称 Frontiers in Endocrinology
作者
Yunxia Zhu; Chenxi Ren; Mingliang Zhang; Yuan Zhong;
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作者单位

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年(卷),期 2020(11),-1
年度 2020
页码 -1
总页数 14
原文格式 PDF
正文语种
中图分类情报学;
关键词
perilipin5; oxidative stress; pancreatic β-cells; free fatty acid; Nrf-2; MAPK;

机译：周脂质5;氧化应激;胰腺β细胞;游离脂肪酸;Nrf-2;MAPK;

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专利

1. Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells [J] . Yunxia Zhu, Chenxi Ren, Mingliang Zhang, Frontiers in Endocrinology . 2020,第2期

机译：Perilipin 5通过在INS-1胰腺β细胞中激活PI3K / ERK介导的NRF2是信号传导途径来减少与脂毒性相关的氧化损伤
2. Morin activates the Nrf2-ARE pathway and reduces oxidative stress-induced DNA damage in pancreatic beta cells [J] . Vanitha Pachamuthu, Senthilkumar Sankareswaran, Dornadula Sireesh, European Journal of Pharmacology: An International Journal . 2017,第期

机译：Morin激活NRF2是途径，并减少胰腺β细胞中的氧化应激诱导的DNA损伤
3. Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway [J] . Wang Chunjing, Liao Yaping, Wang Shengnan, Molecular medicine reports . 2018,第5aPta2期

机译：通过激活NRF2 - 信号通路对二氟嗪对过氧化氢诱导的L02细胞氧化损伤的细胞保护作用
4. The Role of the PI3K Pathway in Anti-IgM (Anti-i) - ensitive and -Resistant B-cell Lymphomas Failure to Disengage PI3K Pathway Signaling Confers i-fi Resistance on the CH12 B Cell Lymphoma [C] . Gregory B. Carey, Laura Tonnetti, David W. Scott International Symposium on Programmed Cell Death . 2003

机译：PI3K途径在抗IgM（抗IgM（抗-Ig）的作用 - 最终和 - 抗生素B细胞淋巴瘤未脱离PI3K途径信号传导对CH12 B细胞淋巴瘤的I-FI阻力
5. Estrogen Receptor Activation Suppresses Lipogenesis and Reduces Lipid Accumulation in Pancreatic Islets and Prevents Lipotoxic beta-cell Failure [D] . Tiano, Joseph P. 2012

机译：雌激素受体激活抑制胰岛的脂肪生成并减少脂质积累，并防止脂毒性β细胞衰竭
6. Silencing of soluble epoxide hydrolase 2 gene reduces H2O2-induced oxidative damage in rat intestinal epithelial IEC-6 cells via activating PI3K/Akt/GSK3β signaling pathway [O] . Jun Li, Jihui Luo, Yang Zhang, 2020

机译：可溶性环氧化物水解酶2基因的沉默通过激活PI3K / AKT /GSK3β信号通路降低了大鼠肠上皮IEC-6细胞中的H 2 O 2诱导的氧化损伤
7. Flaccidoxide-13-Acetate Extracted from the Soft Coral Cladiella kashmani Reduces Human Bladder Cancer Cell Migration and Invasion through Reducing Activation of the FAK/PI3K/AKT/mTOR Signaling Pathway [O] . Choo-Aun Neoh, Wen-Tung Wu, Guo-Fong Dai, 2017

机译：从软珊瑚Cladiella kashmani中提取的Flacidoxide-13-acetate通过减少FaK / pI3K / aKT / mTOR信号通路的活化减少人类膀胱癌细胞的迁移和侵袭

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

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