Efficacy and safety of four doses of glycopyrrolate/formoterol fumarate delivered via a metered dose inhaler compared with the monocomponents in patients with moderate-to-severe COPD

机译：经定量吸入器给药的四剂格隆溴铵/福莫特罗富马酸酯与单组分相比在中重度COPD患者中的疗效和安全性

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PurposeTo determine the efficacy and safety of glycopyrrolate/formoterol fumarate metered dose inhaler (GFF MDI 36/9.6, 36/7.2, 18/9.6, 9/9.6 µg) using innovative co-suspension delivery technology, compared with glycopyrrolate (GP) MDI 36 µg and formoterol fumarate (FF) MDI 9.6 µg, in patients with moderate-to-severe COPD.

机译：目的使用创新的共悬浮输送技术与格隆溴铵（GP）MDI 36相比，确定格隆溴铵/福莫特罗富马酸富马酸酯计量吸入器（GFF MDI 36 / 9.6、36 / 7.2、18 / 9.6、9 / 9.6 µg）的疗效和安全性微克和富马酸福莫特罗（FF）MDI 9.6微克，适用于中度至重度COPD患者。

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期刊名称 International Journal of Chronic Obstructive Pulmonary Disease
作者
Colin Reisner; James Pearle; Edward M Kerwin; Earl St Rose; Patrick Darken;
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作者单位

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年(卷),期 2018(13),-1
年度 2018
页码 1965–1977
总页数 13
原文格式 PDF
正文语种
中图分类呼吸生理学;
关键词
bronchodilator chronic obstructive pulmonary disease co-suspension delivery technology fixed-dose combination LAMA/LABA long-acting β2-agonist long-acting muscarinic antagonist;

机译：支气管扩张药;慢性阻塞性肺疾病;共悬浮给药技术;固定剂量组合;LAMA / LABA;长效β2-激动剂;长效毒蕈碱拮抗剂;

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1. Efficacy and safety of four doses of glycopyrrolate/formoterol fumarate delivered via a metered dose inhaler compared with the monocomponents in patients with moderate-to-severe COPD [J] . Colin Reisner, James Pearle, Edward M Kerwin, International Journal of Chronic Obstructive Pulmonary Disease . 2018,第1期

机译：经定量吸入器给药的四剂格隆溴铵/福莫特罗富马酸酯与单组分相比在中重度COPD患者中的疗效和安全性
2. A multicenter, randomized, double-blind dose ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropiurn dry powder inhaler in patients with moderate-to-severe COPD (vol 120, pg 16, 2016) [J] . Tashkin Donald P., Martinez Fernando J., Rodriguez-Roisin Roberto, Respiratory medicine . 2017,第期

机译：糖类吡咯酸酯/福特蛋白酶富马特固定剂组合计量计量剂量吸入器的多中心，随机的双盲剂量测量研究与中间组成和开放标签的抗乳粉吸入器中度至严重的COPD患者（Vol 120，PG 16 ，2016）
3. A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropium dry powder inhaler in patients with moderate-to-severe COPD [J] . Tashkin Donald P., Martinez Fernando J., Rodriguez-Roisin Roberto, Respiratory medicine . 2016,第Null期

机译：与中成重度COPD患者单组分和开放标签噻托溴铵干粉吸入器相比，格隆溴铵/富马酸福莫特罗固定剂量联合剂量吸入器的多中心，随机，双盲剂量范围研究
4. THE EFFICACY OF A NEW ALBUTEROL METERED DOSE POWDER INHALER IN COMPARISON WITH TWO OTHER INHALER DEVICES [C] . Seppaelae, O-P., Aalto, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：新型沙丁胺醇计量剂量粉末吸入器与其他两种吸入器设备的功效
5. Importance of metering valve-formulation interactions on electrical properties in hydrofluoroalkane-based pressurized metered dose inhalers [D] . Kulphaisal, Prapaporn 2002

机译：在基于氢氟烷烃的加压定量吸入器中，计量阀-配方相互作用对电性能的重要性
6. Efficacy safety and pharmacokinetics of budesonide/formoterol fumarate delivered via metered dose inhaler using innovative co-suspension delivery technology in patients with moderate-to-severe COPD [O] . Edward M Kerwin, Thomas M Siler, Samir Arora, 2018

机译：使用创新的混悬液输送技术通过计量吸入器输送布地奈德/福莫特罗富马酸酯的功效安全性和药代动力学用于中重度COPD患者
7. A multicenter, randomized, double-blind dose-ranging study of glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler compared to the monocomponents and open-label tiotropium dry powder inhaler in patients with moderate-to-severe COPD [O] . Tashkin Donald P., Martinez Fernando J., Rodriguez-Roisin Roberto, 2016

机译：与中成重度COPD患者的单组分和开放标签噻托铵干粉吸入器相比，格隆溴铵/富马酸福莫特罗固定剂量联合剂量吸入器的多中心，随机，双盲剂量范围研究

Efficacy and safety of four doses of glycopyrrolate/formoterol fumarate delivered via a metered dose inhaler compared with the monocomponents in patients with moderate-to-severe COPD

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