Synthesis and Evaluation of Some Novel Chromone Based Dithiazoles as Antimicrobial Agents

摘要

Novel substituted 1,2,4-dithiazolylchromones >3a–j were synthesized by the reaction of 3-formylchromones (>1a–j) with two equivalents of p-chlorothiobenzamide (>2) in dry xylene and characterized spectroscopically (IR, ¹H and ¹³C NMR, mass) and elemental analysis. All synthesized compounds were screened for in vitro antimicrobial activity against various pathogenic bacterial and fungal strains and were found to possess good to moderate inhibitory potential against all tested strains. Antimicrobial results reveal that compounds bearing lipophilic electron withdrawing groups such as chloro and bromo displayed significant inhibitory potential against both bacterial and fungal strains. Particularly, compound >3c displayed significant inhibitory against bacterial strains and compound >3h exhibits significant inhibitory potential in comparison to standard drug fluconazole against fungal strain S. cerevisiae.