Synthesis and In Vitro Antimicrobial Evaluation of New 134-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety

摘要

A series of new 1,3,4-oxadiazole derivatives, >4(a–h), containing 5-chloro-2-methoxy benzohydrazide moiety were synthesized by the reaction of 5-chloro-2-methoxybenzoate with different aromatic carboxylic acids. These newly synthesized compounds were characterized by FT-IR, ¹H NMR, mass spectra, and also by elemental analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that compounds >4c, >4f, and >4g showed significant activity against tested strains.