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Trough level of infliximab is useful for assessing mucosal healing in Crohns disease: a prospective cohort study

机译：英夫利昔单抗的低水平可用于评估克罗恩病的粘膜愈合：一项前瞻性队列研究

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Background/AimsDecreased trough levels of infliximab (TLI) and antibodies to infliximab (ATI) are associated with loss of response (LOR) in Crohn's disease. Two prospective studies were conducted to determine whether TLI or ATI better correlates with LOR (Study 1), and whether TLI could become a predictor of mucosal healing (MH) (Study 2).

机译：背景/目的英夫利昔单抗（TLI）和英夫利昔单抗抗体（ATI）的低谷水平与克罗恩病的反应丧失（LOR）有关。进行了两项前瞻性研究，以确定TLI或ATI是否与LOR更好相关（研究1），以及TLI是否可以成为粘膜愈合（MH）的预测因子（研究2）。

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期刊名称 Intestinal Research
作者
Akihiro Koga; Toshiyuki Matsui; Noritaka Takatsu; Yasumichi Takada; Masahiro Kishi; Yutaka Yano; Takahiro Beppu; Yoichiro Ono; Kazeo Ninomiya; Fumihito Hirai; Takashi Nagahama; Takashi Hisabe; Yasuhiro Takaki; Kenshi Yao; Hirotsugu Imaeda; Akira Andoh;
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年(卷),期 2018(16),2
年度 2018
页码 223–232
总页数 18
原文格式 PDF
正文语种
中图分类外科学;
关键词
Crohn disease Infliximab trough level Mucosal healing Loss of response Antibodies to infliximab;

机译：克罗恩病;英夫利昔单抗谷水平;粘膜愈合;反应丧失;英夫利昔单抗抗体;

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专利

1. Trough level of infliximab is useful for assessing mucosal healing in Crohn's disease: a prospective cohort study [J] . Koga Akihiro, Matsui Toshiyuki, Takatsu Noritaka, Intestinal research. . 2018,第2期

机译：英夫利昔单抗的低水平可用于评估克罗恩病的粘膜愈合：一项前瞻性队列研究
2. Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn's Disease [J] . Kang Ben, Choi So Yoon, Choi Young Ok, Journal of Crohn’s & colitis . 2019,第2期

机译：英夫利昔单抗水平与在儿科克罗恩病的嗜活增生期间的维持治疗期间粘膜愈合有关
3. Subtherapeutic Infliximab Trough Levels and Complete Mucosal Healing Are Associated With Sustained Clinical Remission After Infliximab Cessation in Paediatric-onset Crohn's Disease Patients Treated With Combined Immunosuppressive Therapy [J] . Kang Ben, Choi So Yoon, Choi Young Ok, Journal of Crohn’s & colitis . 2018,第6期

机译：亚治疗性英夫利昔单抗水平和完全粘膜愈合与血红素急性抑制治疗治疗治疗患者的血红素突破后持续临床缓解相关
4. Importance of mucosal healing in Crohn's disease and ulcerative colitis [C] . G. D HAEN Falk Symposium . 2007

机译：粘膜疾病和溃疡性结肠炎粘膜愈合的重要性
5. A Cost-utility Analysis of Biosimilar Infliximab Compared to Reference Infliximab in Adult Switch Patients with Crohn's Disease: A Canadian Analysis [D] . Hughes, Avery. 2018

机译：生物纤维生素infiximab的成本实用性分析与成人交换患者参考incriximab患者克罗恩病患者：加拿大分析
6. Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn’s Disease in Children [O] . Wael El-Matary, Thomas D Walters, Hien Q Huynh, -1

机译：较高的诱导英夫利昔单抗血清谷水平与儿童瘘管性肛周克罗恩病的愈合有关
7. Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease [O] . Ben Kang, So Yoon Choi, Young Ok Choi, 2018

机译：英夫利昔单抗水平与在儿科克罗恩病中英夫利昔单抗的维持治疗期间与粘膜愈合有关

Trough level of infliximab is useful for assessing mucosal healing in Crohns disease: a prospective cohort study

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