The Potential of 13C Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition

摘要

The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of ¹³C-labeled odorants. The application of ¹³C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs' free energies (ΔG) for acetophenone and octan-1-ol, two odorants for which the ²D (deuterium) isotopomers have previously been shown to be discernible from their respective ¹H (normal) counterparts by Drosophila melanogaster.