The ovarian response to standard gonadotrophin stimulation depends on FSHR SHBG and CYP19 gene synergism

摘要

PurposeFollicle stimulating hormone, sex hormone-binding globulin and cytochrome P450 aromatase play crucial roles in the regulation of mammalian reproduction. The synergistic effect of FSHR 307(T/A)/FSHR 680(N/S), SHBG(TAAAA)n and CYP19(TTTA)n genotypes on ovarian response to standard gonadotrophin stimulation of women undergoing medically assisted reproduction (IVF/ICSI) was explored.