Short Communication: FSH Time-Concentration Profiles Before and After Administration of 0.25 mg Cetrorelix in the GnRH-Antagonist Multiple-Dose Protocol for Ovarian Hyperstimulation

摘要

>Purpose: To determine FSH concentration behavior before and after cetrorelix 0.25 mg administration in the GnRH-antagonist multiple-dose protocol on day 6 of ovarian stimulation with 150–300 IU daily recombinant FSH.>Methods: Blood samples for FSH measurements were drawn from seven women every 15 min from 8 h prior to the first cetrorelix administration in the GnRH-antagonist multiple-dose protocol until 15–32 h thereafter.>Results: No significant change of FSH concentration was observed.>Conclusions: This observation indicates that no rationale exists of increasing the daily FSH dosage concomitantly to the GnRH-antagonist administration to compensate for a drop of endogenous FSH.