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Developing a semantically rich ontology for the biobank-administration domain

机译:为生物库管理领域开发语义丰富的本体

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摘要

BackgroundBiobanks are a critical resource for translational science. Recently, semantic web technologies such as ontologies have been found useful in retrieving research data from biobanks. However, recent research has also shown that there is a lack of data about the administrative aspects of biobanks. These data would be helpful to answer research-relevant questions such as what is the scope of specimens collected in a biobank, what is the curation status of the specimens, and what is the contact information for curators of biobanks. Our use cases include giving researchers the ability to retrieve key administrative data (e.g. contact information, contact's affiliation, etc.) about the biobanks where specific specimens of interest are stored. Thus, our goal is to provide an ontology that represents the administrative entities in biobanking and their relations. We base our ontology development on a set of 53 data attributes called MIABIS, which were in part the result of semantic integration efforts of the European Biobanking and Biomolecular Resources Research Infrastructure (BBMRI). The previous work on MIABIS provided the domain analysis for our ontology. We report on a test of our ontology against competency questions that we derived from the initial BBMRI use cases. Future work includes additional ontology development to answer additional competency questions from these use cases.
机译:背景生物库是转化科学的重要资源。最近,发现诸如本体之类的语义网络技术可用于从生物库检索研究数据。但是,最近的研究也表明,缺乏有关生物库管理方面的数据。这些数据将有助于回答与研究相关的问题,例如在生物库中收集的标本的范围是什么,标本的管理状态是什么,以及生物库管理者的联系信息是什么。我们的用例包括使研究人员能够检索有关存储特定目标标本的生物库的关键管理数据(例如,联系信息,联系人的隶属关系等)。因此,我们的目标是提供一个代表生物银行及其关系中的行政实体的本体。我们基于53个数据属性(称为MIABIS)进行本体开发,这部分是欧洲生物银行和生物分子资源研究基础架构(BBMRI)进行语义集成的结果。 MIABIS的先前工作为我们的本体提供了领域分析。我们报告了针对本体能力的测试,这些测试是根据最初的BBMRI用例得出的能力问题。未来的工作包括其他本体开发,以回答这些用例中的其他能力问题。

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