Genome Technology Center at the NYU Langone Medical Center: New Support for Clinical and Translational Science

摘要

To significantly enhance support for clinical and translational research within the framework of its CTSI, the NYU Langone Medical Center consolidated the Microarray and DNA Sequencing Cores into a new Genome Technology Center, a shared resource overseen by the Office for Collaborative Science. The GTC's team of 4 technical personnel and one faculty level director assists >120 NYULMC laboratories in their basic, clinical and translational research. The Sequencing Unit operates 2 Illumina GAIIs, and a HiSeq sequencer will be added in Q1 2011. The GAII capacity is applied to research applications (ChIP-seq, small-RNA-seq and RIP-seq) and to identification of disease-related genome-level structure changes and correlates (e.g. RNA-seq of cancer transcriptomes). GTC also has a Roche GS FLX System (454) used for de novo sequencing of microbial species and for amplicon sequencing in clinical genetics, patient microbiome diversity, etc. The Microarray Unit operates Affymetrix GeneChip system and high-capacity QPCR (ABI 7900HT) with automated plate setup and loading for gene and microRNA profiling and for SNP genotyping in clinical genetics. The GTC cooperates closely with the newly established Center for Health Informatics and Bioinformatics (CHIBI) supported by the NIH/NCRR CTSA Award. CHIBI provides an HPC facility for sequencing and microarray data storage and offers a full range of informatics services. The GTC is committed to regional and nationwide collaborations with other Cores. GTC participates in the activities of the Genomic Analysis and Technology Excellence (GATE) Working Group of the Academy for Medical Development and Collaboration (AMDeC), particularly in the sections of Core Facility Directors, Funding Strategy and Bioinformatics. It also contributes to the AMDeC Facilities Instrumentation Resources Services Technologies (FIRST), a real-time online database of biomedical research technology and resources available in the New York City area and throughout Northeastern US. Key services of the GTC are offered to external clients.