Isomangiferin a Novel Potent Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor Suppresses Breast Cancer Growth Metastasis and Angiogenesis

摘要

PurposeVascular endothelial growth factor (VEGF) signal transduction mainly depends on its binding to VEGF receptor 2 (VEGFR-2). VEGF downstream signaling proteins mediate several of its effects in cancer progression, including those on tumor growth, metastasis, and blood vessel formation. The activation of VEGFR-2 signaling is a hallmark of and is considered a therapeutic target for breast cancer. Here, we report a study of the regulation of the VEGFR-2 signaling pathway by a small molecule, isomangiferin.