Author contributions: Guarantor of integrity of entire study, D.P.; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; approval of final version of submitted manuscript, all authors; agrees to ensure any questions related to the work are appropriately resolved, all authors; literature research, D.P., R.D., J.S., J.R., T.K.; clinical studies, D.P., R.D., P.G.M., J.S., T.K.; experimental studies, R.D., J.H., J.Y., L.D.S.; statistical analysis, R.D., J.H., D.V.D.V.; and manuscript editing, all authors
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