Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits

摘要

Oncolytic viruses can be a potent tool in the fight against cancer. However, in clinical settings their ability to replicate in and kill tumors is often limited. Combinations with specific small molecule compounds can address some of these limitations and help oncolytic viruses reach their full potential. The aim of this review is to provide an overview of the different types of small molecules with which oncolytic viruses can achieve therapeutic synergy. We focus on the underlying mechanisms in three functional areas: combinations that increase viral replication, enhance tumor cell killing and improve antitumor immune responses.