Regardless of the classification of initial injury severity, traumatic brain injury (TBI) canresult in debilitating neurologic and psychiatric symptoms that may last months to years.1 These post-TBI symptoms can vary widely from patient to patient, but core symptomsinvolve depressed mood and cognitive impairment.1 The underlying pathophysiology of persistent cognitive dysfunction following TBI hasyet to be fully understood, but disruptions in large scale neural networks, particularly thosegoverning resting state functional connectivity (e.g., default mode network) and cognitivecontrol (e.g., salience network), are strongly implicated across TBI severities.2 Furthermore, the presence of post-traumatic depression may have bi-directionalinteractions on prolonging the overall recovery process.3 Given the deficits in multiple domains of functioning following TBI, novelrehabilitation approaches that can target multiple symptoms simultaneously are needed for thiscomplex neuropsychiatric patient population.
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