Comparison of Microvascular Permeability Measurements Ktrans Determined with Conventional Steady-State T1-Weighted and First-Pass T2*-Weighted MR Imaging Methods in Gliomas and Meningiomas

摘要

BACKGROUND AND PURPOSE: The widely accepted MR method for quantitating brain tumor microvascular permeability, Ktrans, is the steady-state T1-weighted gradient-echo method (ssT1). Recently the first-pass T2*-weighted (fpT2*) method has been used to derive both relative cerebral blood volume (rCBV) and Ktrans. We hypothesized that Ktrans derived from the ssT1 and the fpT2* methods will correlate differently in gliomas and meningiomas because of the unique differences in morphologic and functional status of each tumor vascular network.