Diffusion-weighted imaging (DWI) is most recognized for its diagnostic utility in stroke; however, recent attention has focused on other diseases that similarly exhibit restricted diffusion on DWI. DWI of blood clot is of particular interest because hemorrhage may complicate the appearance of stroke. Because the process of clotting involves transformation of a fluid to a semisolid, it is predictable that water diffusion would decrease in acute clot and hence be hyperintense on DWI. Thus, the AJNR articles by Atlas et al (1) and Maldjian et al (2) focusing on the diffusion characteristics of intracerebral hematomas are of interest in that they represented early, albeit incomplete, studies of the diffusion characteristics of blood clot as a function of time.
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