Introduction: Since its discovery in 1921, insulin has served as the mainstay of treatment for patients with both type 1 and insulin-dependent type 2 diabetes mellitus (T2DM). Insulin is available in both long and short acting formulations. Glargine, a long-acting insulin, has an onset of action in one to two hours and length of duration of 24 hours. Although generally well tolerated, when taken in overdose, insulin can lead to severe hypoglycemia, seizures, unconsciousness, or even death. We present a case of an insulin-dependent male with refractory hypoglycemia after an intentional glargine overdose.
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