Gravity in the brain—how it may regulate skeletal muscle metabolism by balancing compressive ischemic changes in the weight‐bearing pituitary and hypothalamus

摘要

Recently in the Journal, a group of metabolism physiology investigators (Lamon et al., 2021) reported on their controlled study of sleep deprivation in normal healthy adults by looking at skeletal muscle protein synthesis, and specific hormone levels, as well as gene expression. They found that muscle protein synthesis was significantly reduced in sleep deprivation, compared to their control group. Sleep deprivation was also associated with an increase in plasma cortisol levels, and a decrease in plasma testosterone levels, compared to controls. Analysis of gene expression via muscle biopsy revealed no significant difference between sleep deprivation and the control group, suggesting no alteration of gene regulation during sleep deprivation.