Modest Improvements in Refractory Antibody-Mediated Rejection After Prolonged Treatment

摘要

Changes in DSA across the first year after cABMR diagnosis. The MFI of (a) class II DSA, (b) class I DSA, and (c) total DSA was evaluated by Luminex at the time of index, 3-month, 6-month, and 12-month biopsies. There was a decrease in class II DSA (P = 0.02) and total DSA (P = 0.03) in the course of the follow-up period at 3-month, 6-month, and 12-month biopsies compared with the index biopsy. Class I DSA resolved by 3 months posttreatment, but it was not statistically significant owing to the small sample size. MFI values for patient 2 are missing at 6 and 12 months (designated by X) owing to the decline in graft function, but the patient remained positive for class II DSA until the graft was lost. Data were evaluated for normality using the D’Agostino and Pearson tests and then analyzed using the ANOVA mixed effects test with significance designated as #P ≤ 0.05. Follow-up with Student’s t test is found with significance designated as ∗P < 0.05 (compared with index biopsy). Data are expressed as the mean ± SD. ANOVA, analysis of variance; cABMR, chronic active antibody-mediated rejection; DSA, donor-specific antibody; MFI, mean fluorescence intensity; SD, standard deviation.