Ultra-High Dose Rate Transmission Beam Proton Therapy for Conventionally Fractionated Head and Neck Cancer: Treatment Planning and Dose Rate Distributions

摘要

Standard intensity-modulated proton therapy (IMPT) places the Bragg-peak in the target. However, it is also possible to use high energy proton transmission beams (TBs), where the Bragg-peak is placed outside the patient, irradiating with the beam section proximal to the Bragg-peak. TBs use only one energy, increase robustness, are insensitive to density changes and have sharper penumbras. TBs can also be delivered at ultra-high dose-rates (UHDRs, e.g., ≥40 Gy/s), which is one of the requirements for the FLASH-effect. The aim of this work was twofold: (1) comparison of TB-plan quality to IMPT and photon volumetric-modulated arc therapy (VMAT) for conventionally fractionated head-and-neck cancer; (2) analysis of TB-plan UHDR-metrics. We showed that TB-plan quality was comparable to IMPT for contoured organs at risk and better than VMAT. Any potential FLASH-effect would only further improve plan quality. TB plans can also be delivered quickly, which might facilitate higher patient through-put and enhance patient comfort.