Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines

摘要

The information of fast-spreading SARS-CoV-2 variants. a Detailed amino acid mutations of SARS-CoV-2 variants (B.1.1.7, B.1.351, B.1.1.28.1) and key mutations are marked in red. b The major structure of SARS-CoV-2, including spike protein, membrane protein, envelope protein, nucleocapsid protein and RNA. As a transmembrane protein, angiotensin-converting enzyme 2 (ACE2) serves as the main entry point into cells for SARS-CoV-2