Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study

摘要

The mean number of NMS in PD increased from 7.5 (SD 4.9) at baseline to 9.5 (SD 5.2) after 3 years. The composition of the number of NMS at each visit was presented in Fig. 1 as well. Increased number of NMS were observed in D1 (mean 0.3–0.7), D2 (mean 1.3–1.9), D4 (mean 0.1–0.2), D5 (mean 1.1–1.4), D6 (mean 0.5–1.0), D7 (mean 0.8–1.2), and D9 (mean 1.0–1.4) domains from baseline to 3-year. The number of NMS in the D8 domain was decreased from mean 0.7 at baseline to mean 0.5 after 3 years. Abbreviations: NMS non-motor symptoms, PD Parkinson’s disease.