Central amygdala circuitry modulates nociceptive processing through differential hierarchical interaction with affective network dynamics

摘要

a Expression of pain-related genes expressed in CEl. Distribution of 54 expressed (transcripts per million, TPM > 1) genes (Supplementary Data 3) in PKCδ+ (blue) or SST+ populations (red). b CEl PKCδ+ or SST+ neurons differentially express (DE) components of the molecular interaction network from the pain-related gene set (Supplementary Data 3). Blue or red node color represents DESeq2 log2FoldChange of the expressed genes (a) in either of the cell types, thick node border marking genes with significant differential expression with adjusted P value padj < 0.1. Genes in the network not expressed (TPM < 1) are gray. For abbreviations of genes, see Supplementary Data 3.