Analysis of the evolutionary path and hotspots of innate lymphoid cells based on a knowledge map

摘要

To the Editor: Innate lymphoid cells (ILCs) are a heterogeneous population of lymphocytes that lack specific antigen receptors and yet produce effective cytokines to match the T helper cell subsets.[1] For the past decade, the discovery of these cells and research on this topic have revealed that ILCs are tissue resident cells that have multiple immune roles, such as regulating tissue inflammation, tissue remodeling and metabolic homeostasis, by the effector functions of their subsets and are involved in diseases such as asthma, allergic rhinitis, inflammatory bowel disease, and cancer. Various publications have sorted and summarized the research results in this field, but these reports were descriptive literature reviews and qualitative taxonomic research that cannot fully and objectively reflect the whole picture of ILC research. The purpose of this study to evaluate the development of ILC and explore the future prospects of this research by examining the evolutionary path of hotspots and the distribution of time and geographic region in ILC research.