Abstract 115: Unlike A Conditioning Crush Lesion Conditioning Electrical Stimulation Promotes Functional Sensory And Motor Nerve Regeneration In A Non-inflammatory Manner

摘要

Purpose: Prior to a nerve repair, conditioning electrical stimulation (CES) promotes regeneration associated gene (RAG) expression at the neuronal cell bodies and promotes functional nerve regeneration as well as, or beyond that of a conditioning crush lesion (CCL) (Senger et al., 2017; 2019). Forty years of research has established that the inflammatory response evoked by the CCL injury prior to the cut and coaptation is essential to the conditioning response. It is not known how CES promotes nerve regeneration. We propose that CES promotes functional nerve regeneration in a non-injurious, and non-inflammatory manner.