Developmental exposure to near roadway pollution produces behavioral phenotypes relevant to neurodevelopmental disorders in juvenile rats

摘要

a Pregnant female rats were transported to the roadside exposure facility at approximately gestational day (GD) 14 and were randomly assigned to be housed in either the TRAP or filtered air (FA) exposure chambers. Offspring, remained in the exposure condition into which they were born, were tested on a variety of developmental milestone assays between four days after birth (postnatal day (PND) 4) and weaning at PND 21 and then a battery of standardized behavioral assays between PND 21 and 50. b, c Particulate matter (PM) concentrations of the TRAP air and FA were quantified on 19 days. Both b PM2.5 and c PM10 concentrations of the TRAP air were significantly higher than those of the FA. *p < 0.05, paired t-test.