DESTINATION: a phase 3 multicentre randomized double-blind placebo-controlled parallel-group trial to evaluate the long-term safety and tolerability of tezepelumab in adults and adolescents with severe uncontrolled asthma

摘要

Mechanism of action by which tezepelumab improves clinical outcomes in patients with severe asthma. TSLP is released from the airway epithelium in response to insults such as viruses, allergens and pollutants, triggering multiple inflammatory cascades. Tezepelumab specifically blocks TSLP from binding to its heterodimeric receptor, thereby inhibiting the production of various inflammatory cytokines and cell types. Treatment with tezepelumab has thus far been shown to reduce blood eosinophil count, IgE, IL-5, IL-13 and FeNO. FeNO fractional exhaled nitric oxide, IgE immunoglobulin E, IL interleukin, ILC2 type 2 innate lymphoid cell, Th T‑helper, TSLP thymic stromal lymphopoietin