Chemoradioimmunotherapy of inoperable stage III non-small cell lung cancer: immunological rationale and current clinical trials establishing a novel multimodal strategy

摘要

Abscopal effect in preclinical model adapted from Demaria et al. [18]: Mice bearing a syngeneic mammary carcinoma (67NR) in both flanks were treated with growth factor Flt3-Ligand (Flt3-L) or local radiation therapy to one of the two tumors or combined treatment. The Flt3-L was used to enhance the number of available dendritic cells. Administering Flt3-L had no effect on tumor growth delay (a, b). RT alone led to tumor growth delay of the irradiated tumor (c, d). Combination treatment resulted in tumor growth delay in both flanks (e, f) in contrast to T cell deficient mice where no tumor growth delay of nonirradiated tumor was observed (g, h)