Antidepressant-Like Action of Single Facial Injection of Botulinum Neurotoxin A is Associated with Augmented 5-HT Levels and BDNF/ERK/CREB Pathways in Mouse Brain

摘要

BoNT/A treatment decreased the immobility time during FST and TST in naive mice. ICR mice received a single facial injection of BoNT/A (0.02, 0.06, and 0.18 U), and the FST (A) and TST (B) were performed at different time points. Motor function and locomotion activity were assessed by the Rotarod test (C) and open field test (D–F), respectively. *P <0.05, **P <0.01, ***P <0.001 vs. control mice (two-way ANOVA with post-hoc Bonferroni test). The data are presented as mean ± SEM, n = 5–10/group. Con, control; BL, baseline; Imi, imipramine.