Chronic non-discriminatory social defeat is an effective chronic stress paradigm for both male and female mice

摘要

CNSDS paradigm induces attacks to both male and female C57BL/6J mice. a Schematic representation of CNSDS paradigm. b CD1 aggressors attack male quicker (***t(28) = 3.85, p = 0.006) and more (***t(28) = 3.7, p = 0.009) than female C57BL/6J mice. c The percentage of CD1 behaviors directed towards male and female mice over the 10-day CNSDS protocol. Behaviors directed towards females were further investigated over the course of the estrous cycle. d Percentage of CD1s that attacked males or females over the 10-day CNSDS protocol