Conditional knockout of leptin receptor in neural stem cells leads to obesity in mice and affects neuronal differentiation in the hypothalamus early after birth

摘要

Specific depletion of Lepr in nestin-expressing progenitor cells leads to obesity. a No obvious phenotype of the Shh-Cre;Leprflox/flox(Shh-cKO) mice compared with control littermates examined at P35 or P70, as indicated (upper panel). No difference in body weight of the Shh-cKO mice compared with control littermates examined during the first 10 weeks after birth (lower panel). bNes-Cre;Leprf/f (Nes-cKO) mice display severe obesity (upper panel) at P35 or P70 and a significant increase of body weight from week 5 compared with control littermates (lower panel). (n ≥ 10 mice per group)