Activation and enhancement of caerulomycin A biosynthesis in marine-derived Actinoalloteichus sp. AHMU CJ021 by combinatorial genome mining strategies

摘要

Genome map of Actinoalloteichus sp. AHMU CJ021. The genomic information is represented as five circles that depict the following (from outer to inner): (1) and (2) CDS in the sense strand and antisense strand, respectively, with genes coloured according to their COG functional annotations (listed on right); (3) locations of predictive secondary metabolite clusters; (4) G + C content (0–100%) as plotted using a sliding window, as the derivation from the average GC content of the entire sequence. The red peaks and blue peaks indicate the G + C content of the entire sequence in the sense strand and antisense strand, respectively. (5) GC skew (G − C/G + C), as plotted as the deviation from the average GC skew (0–50%) of the entire sequence. The pink peaks and blue-green peaks indicate the G + C content of the entire sequence in the sense strand and antisense strand, respectively