OR26-02 The Effect on Ketogenesis of Withholding Early Parenteral Nutrition in Critically Ill Children as a Potential Mediator of the Improved Acute Outcome

摘要

Introduction: In adults and children, withholding parenteral nutrition (PN) for 1 week in ICU (late PN), hereby accepting macronutrient deficit early during critical illness, as compared with supplementing insufficient enteral nutrition with PN (early PN), accelerates weaning from mechanical ventilation, reduces infections, and shortens ICU stay1,2. We hypothesized that these benefits are in part mediated by fasting-induced ketogenesis.