Efflux Pumps Contribute to Intrinsic Clarithromycin Resistance in Clinical Mycobacterium abscessus Isolates

摘要

The emergence of clarithromycin resistance is a challenge in treating Mycobacterium abscessus infections. Known mechanisms that contribute to intrinsic clarithromycin resistance focus on rrl gene-related mutations, but resistant clinical isolates often exhibit an inconsistent rrl genotype.