Evaluating the genetic architecture of quantitative traits via selection followed by inbreeding

摘要

Assessing the contribution of intermediate-frequency alleles and rare, partially recessive alleles to quantitative trait variation (QTV) through selection and inbreeding. a The ratio ΔB/ΔM, where ΔM is the change in trait mean with selection and ΔB is the difference in directional dominance (B) between the control (BC) and selected (BS) lines, is an indicator of the contribution of rare, partially recessive alleles to QTV (Kelly 1999). b When ΔB/ΔM ~ 1, QTV is caused by rare, partially recessive alleles. c When ΔB/ΔM ~ 0, QTV is caused by intermediate-frequency alleles. ΔB/ΔM was calculated assuming F = 0.5. Note that these equations are the same if the selected population was represented by the open circles, and the control population represented by the closed circles (i.e. selection for higher trait values)