Identification of MMP1 as a potential gene conferring erlotinib resistance in non-small cell lung cancer based on bioinformatics analyses

摘要

Identification and functional characterization of DEGs from {"type":"entrez-geo","attrs":{"text":"GSE80344","term_id":"80344"}}GSE80344 dataset. a The DEGs volcano plot was analyzed between erlotinib resistant NSCLC cell lines and erlotinib sensitive cell lines. Green dots were significantly downregulated DEGs, red dots were significantly upregulated DEGs, and black dots were no significant difference (P < 0.01 and |log2FC| ≥ 2 as the threshold cutoff). b The distribution of significant DEGs in erlotinib resistant cells. The number of the upregulated genes was 73 and the downregulated genes was 235. The top 5 GO (c) and KEGG pathways (d) of significantly upregulated DEGs were indicated. MF, molecular function; CC, cellular component; BP, biological process