Hospital Infection Control:Clostridioides difficile

摘要

Clostridioides difficileremains a leading cause of healthcare-associated infection. Efforts atC. difficileprevention have been hampered by an increasingly complex understanding of transmission patterns and a high degree of heterogeneity among existing studies. Effective prevention ofC. difficileinfection requires multimodal interventions, including contact precautions, hand hygiene with soap and water, effective environmental cleaning, use of sporicidal cleaning agents, and antimicrobial stewardship. Roles for probiotics, avoidance of proton pump inhibitors, and isolation of asymptomatic carriers remain poorly defined.