Dynamic changes in chromatin accessibility altered adipogenic gene expression and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming

摘要

Scatter plot of pairwise DNA accessibility comparisons between control and PCOS samples at a day 0, b day 3 and c day 12. Each data point represent a genomic region, and those with significant accessibility difference (FDR < 0.05) between PCOS and control are highlighted in pink. Regions located above the blue horizontal line [log (fold change = 0)] have higher accessibility in PCOS, while those located below the line have lower accessibility. Pie charts below each plot display percentage overlap between significant differentially accessible regions and annotated genes