Regulation of the innate immune system by autophagy: monocytes macrophages dendritic cells and antigen presentation

摘要

Autophagic activity in the differentiation from monocytes to macrophages. Innate immune cells such as macrophages and DCs arise from a hematopoietic stem cell (HSC) that has committed to a common myeloid progenitor (CMP). Monoblasts then further generate a monocytic cell lineage, leading to the development of macrophages and DCs. To date, autophagy is known to be involved in the differentiation step from monocytes to macrophages. Numbers in brackets designate references: + , enhanced function