A 63-year-old man admitted to hospital for the management of a frontal lobe abscess developed elevated liver enzymes within 48 hours of receiving meropenem. Liver enzymes reached a maximum at 5 days postadministration of meropenem, with alanine aminotransferase 1160 U/L, aspartate aminotransferase 787 U/L, alkaline phosphatase 297 U/L and gamma-glutamyltransferase 252 U/L. Meropenem was ceased and liver function normalised. Meropenem was administered for a second time later in the patient’s admission and again the patient developed rapidly increasing liver enzymes, with a mixed hepatocellular/cholestatic pattern. Other possible causes of liver injury were excluded following extensive investigations, and the patient’s liver enzymes continued to normalise following meropenem discontinuation. The patient was asymptomatic during the admission and was transferred to a rehabilitation facility. This case demonstrates that meropenem can cause severe liver injury and that early recognition of drug-induced liver injury is important.
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机译：一名63岁的男子录取医院为管理额叶脓肿的管理，在接受梅洛涅姆的48小时内开发了肝脏酶的升高。肝脏酶在5天达到Meropenem的5天，用丙氨酸氨基转移酶1160 U / L，天冬氨酸氨基转移酶787 U / L，碱性磷酸酶297 U / L和γ-戊二酰转移酶252 U / L.梅洛宁被停止，肝功能标准化。 Meropenem在患者的入场后第二次施用，患者再次产生迅速增加的肝酶，具有混合的肝细胞/胆汁淤积图案。在广泛的调查之后排除了肝损伤的其他可能原因，并且患者的肝酶继续在Meropenem停止后正常化。患者在入场期间无症状，并转移到康复设施。这种情况表明，梅洛涅姆会导致严重的肝损伤，并且早期识别药物诱导的肝损伤是重要的。
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