Classification of four distinct osteoarthritis subtypes with a knee joint tissue transcriptome atlas

摘要

Identification of subtypes from OA cartilage RNA sequencing data. a Heatmap visualization of genes across 131 OA individuals revealed four distinct subtypes (C1–C4). b The upregulated Gene Ontology (GO) terms of each subtype were determined using GAGE. c The downregulated GO terms of C3 were determined using GAGE. In GAGE analysis, stat.mean represents the magnitude of GO term level changes and indicates the direction of the changes