A refractory case of CDK4-amplified spinal astrocytoma achieving complete response upon treatment with a Palbociclib-based regimen:a case report

摘要

Histologic features of the tumor. a H&E section showing diffuse invasion of tumor cells with abundant cytoplasm, indicative of anaplastic oligodendrocytic astrocytoma, WHO III grade; b) IHC showing KI-67: 70% (+); c) IHC showing focal staining of GFAP focal; (+) d) IHC showing strong diffuse staining of Vimentin (+); e) IHC showing CD56 partly (+); f) IHC showing Syn partly (+). Original magnifications: a-f:200×. H&E:haemotoxylin and eosin. IHC: immunohistochemistry