Predicted functional interactome of Caenorhabditis elegans and a web tool for the functional interpretation of differentially expressed genes

摘要

Workflow for inferencing functional interactions between C. elegans genes. High-quality experimentally reported protein interactions were integrated from three databases and were used as positive examples. Six types of functional association evidence from 10 databases were collected to infer putative functional interactions. A total of 10 high-quality feature values were selected from 36 feature values that characterize this evidence with different mathematical representations. Random gene pairs after removing positive examples were used as negative examples. The number of negative examples was 100 times that of the positive examples