Physiologically Based Pharmacokinetic Modeling of CFTR Modulation in People with Cystic Fibrosis Transitioning from Mono or Dual Regimens to Triple-Combination Elexacaftor/Tezacaftor/Ivacaftor

著录项

• 期刊名称 Pulmonary Therapy
• 作者

  Alice Tsai; Shu-Pei Wu; Eric Haseltine; Sanjeev Kumar; Samuel M. Moskowitz; Paul Panorchan; Kushal Shah;

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• 作者单位

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• 年(卷),期 2020(6),2
• 年度 2020
• 页码 275–286
• 总页数 12
• 原文格式 PDF
• 正文语种
• 中图分类 生理学;
• 关键词

  CFTR modulator; Cystic fibrosis; Elexacaftor; Ivacaftor; Lumacaftor; Physiologically based pharmacokinetic modeling; Tezacaftor; Transition modeling; Triple combination;

  机译：CFTR调制器;囊性纤维化;Elexacafeor;Ivacaftor;Lumacaftor;基于生理学的药代动力学建模;Tezacaftor;过渡建模;三重组合;