How do established developmental risk-factors for schizophrenia change the way the brain develops?

摘要

Depicted are four scenarios regarding how abnormal brain development could be a causal factor in patients developing schizophrenia. The four options are described in detail in the text. Options 1–3 have all been outlined previously by others. Option 4 is highly speculative and based largely on observations on dopamine ontogeny in animal models of developmental risk factors for schizophrenia. Thereof course may be many other conceptual models for how abnormal brain development alters brain ontogeny contributing to schizophrenia.