Genetic underpinnings of affective temperaments: a pilot GWAS investigation identifies a new genome-wide significant SNP for anxious temperament in

摘要

Zoomed Manhattan plots of AADGRB3 gene on chromosome 6 for anxious temperament as the outcome phenotype (rs3798978 survived correction for genome-wide significance (p = 4.44 × 10−8), whereas 21 other SNPs showed suggestive significance); BERBB4 gene on chromosome 2 for cyclothymic temperament as the outcome phenotype (4 SNPs showed suggestive significance); and CSHISA6 gene on chromosome 17 for irritable temperament as the outcome phenotype (2 SNPs showed suggestive significance). P-value is displayed in function of genomic position for each single-nucleotide polymorphism (SNP) in the region. Colours denote the r2-value of linkage disequilibrium (LD) with the most significant SNP (marked with asterisk). Gene boundaries and their extension by 10,000 base pairs (as defined for the gene-based tests) are marked with vertical lines.