Resting-state dopaminergic cell firing in the ventral tegmental area negatively regulates affiliative social interactions in a developmental animal model of schizophrenia

摘要

In vivo extracellular single‐unit recordings in the ventral tegmental area (VTA), locus coeruleus (LC), and dorsal raphe nucleus (DRN) of anesthetized rats. a The distributions of firing rates of putative VTA dopaminergic neurons are compared between the EGF model and control rats (n = 48 cells from 5 control rats, n = 46 cells from 5 EGF model rats,). b The distributions of firing rates of putative LC noradrenergic neurons are similar (n = 42 cells from 7 control rats, n = 41 cells from 7 EGF model rats,). c The distribution of firing rates of putative DRN serotonergic neurons are comparable n = 44 cells from 5 control rats, n = 41 cells from 5 EGF model rats). *P < 0.05, Mann–Whitney U test.